Juha Hulmi

 

 

E-mail:

juha.hulmi (at) jyu.fi

 

Degree:

PhD and Docent in exercise physiology. PhD Thesis

 

Current position:

Academy of Finland Research Fellow

1) Department of Biology of Physical Activity
Faculty of Sport and Health Sciences
University of Jyväskylä, Finland

2) Institute of Biomedicine, Physiology, University of Helsinki

 

Research interests:

Strength training, exercise physiology, muscle metabolism and hypertrophy, sport nutrition, biochemistry and molecular biology of muscle, muscle diseases/muscle wasting,  muscle biotechnology

See my new blog (in Finnish): http://lihastohtori.wordpress.com/

https://www.facebook.com/Lihastohtori

https://staff.jyu.fi/Members/jjhulmi/main

 

 

 

 

 

 

 

 

 

Education
University of Jyväskylä: MSc 2004: Exercise Physiology

University of Jyväskylä: PhD 2009: Exercise Physiology

University of Helsinki: Docentship 2013: Exercise Physiology

 

-Basic and cum laude studies in education: qualified teacher in adult education (2008)

Publications (from the oldest to the newest, for links, see Pubmed):

 First author:

1.       Juha J. Hulmi., Jeff S. Volek, Harri Selänne, Antti A. Mero. Protein ingestion prior to strength exercise affects blood hormones and metabolism. Medicine and Science in Sport and Exercise 37: 1990-1997, 2005.

2.      Juha J. Hulmi, Juha P. Ahtiainen, Tuomas Kaasalainen, Eija Pöllänen, Keijo Häkkinen, Markku Alen, Harri Selänne, Vuokko Kovanen, Antti A. Mero. Post-exercise myostatin and activin IIb mRNA levels: effects of strength training. Medicine and Science in Sport and Exercise 39: 289-297, 2007.

3.      Juha J. Hulmi, Vuokko Kovanen, Inna Lisko, Harri Selänne, Antti A. Mero. The effects of whey protein on myostatin and cell cycle related gene expression responses to a single heavy resistance exercise bout in older men. European Journal of Applied Physiology 102: 205-213, 2008.

4.      Juha J. Hulmi, Juha P. Ahtiainen, Harri Selänne, Jeff S. Volek, Keijo Häkkinen, Vuokko Kovanen, Antti A. Mero. Androgen receptors and testosterone in men - effects of protein ingestion, resistance exercise and fiber type. The Journal of Steroid Biochemistry and Molecular Biology 110: 130-137, 2008.

5.      Juha J. Hulmi, Vuokko Kovanen, Harri Selänne, William J. Kraemer, Keijo Häkkinen, Antti A. Mero. Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37: 297-308, 2009.

6.      Juha J. Hulmi, Jörgen Tannerstedt, Harri Selänne, Heikki Kainulainen, Vuokko Kovanen, Antti Mero. Resistance exercise and whey protein ingestion affects mTOR signaling pathway and myostatin in men. Journal of Applied Physiology, 106: 1720-1729, 2009. Published as a Highlighted topic: Regulation of protein metabolism in exercise and recovery.

7.     Juha J. Hulmi, Myllymäki T, Tenhumäki M, Mutanen N, Puurtinen R, Paulsen G, Mero A. Effects of resistance exercise and protein ingestion on blood leukocytes and platelets in young and older men. European Journal of Applied Physiology, 109: 343-53, 2010.

8.     Juha J. Hulmi, Chris Lockwood, Jeffrey S. Stout. Effect of protein/essential amino acids and resistance training on skeletal muscle hypertrophy: A case for whey protein. Review. Nutrition and Metabolism (London) 17;7: 51, 2010.

9.      Juha J. Hulmi, Simon Walker, Juha Ahtiainen, Kai Nyman, William J. Kraemer, Keijo Häkkinen. Molecular signaling in muscle is affected by the specificity of resistance exercise protocol. Scandinavian Journal of Medicine and Science in Sports 2012 22: 240-8

10.  Juha J. Hulmi, Mika Silvennoinen, Riikka Kivelä, Maarit Lehti, Heikki Kainulainen.  Altered REDD1, myostatin and Akt/mTOR/FoxO/MAPK Signaling in Streptozotocin-induced Diabetic Muscle Atrophy. American Journal of Physiology - Endocrinology and Metabolism 2012 302: E307-15

11.  Juha J. Hulmi, Bernardo M. Oliveira, Mika Silvennoinen, Willem M.H. Hoogaars Hongqiang Ma, Philippe Pierre, Arja Pasternack, Heikki Kainulainen, Olli Ritvos. Muscle protein synthesis, mTORC1/MAPK/Hippo signaling and capillary density are altered by blocking of myostatin and activins. American Journal of Physiology - Endocrinology and Metabolism 2013: 304: E41-50.

12.  Juha J. Hulmi, Oliveira BM, Silvennoinen M, Hoogaars WM, Pasternack A, Kainulainen H, Ritvos O. Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin blocked mdx mice. Am J Physiol Endocrinol Metab. 2013: 305: E171-E182.

 

As a coauthor:

13.   Antti A. Mero, Mika Vähälummukka, Juha J. Hulmi, Petteri Kallio, Atte von Wright. Effects of resistance exercise session with the oral ingestion of melatonin on growth hormone concentration and performance in adult men. European Journal of Applied Physiology. 96: 729-739, 2006.

14.  Antti Mero, Anne Leikas, Niina Rinkinen, Petri Huhta, Juha J. Hulmi, Hannu Pitkänen, and Juha Knuutinen. Effect of strength training session on plasma amino acid concentration following oral ingestion of arginine or taurine in men. Amino Acids. 35: 99-106, 2008.

15.  Antti Mero, Anne Leikas, Juha Knuutinen, Juha J. Hulmi. et al. Effect of strength training session on plasma amino acid concentration following oral ingestion of leucine, isoleucine and valine. European Journal of Applied Physiology. 105: 215-223, 2009.

16.  Juha Ahtiainen, Merja Hoffren, Juha J. Hulmi, Mikko Pietikäinen, Antti A. Mero, Janne Avela, Keijo Häkkinen. Panoramic ultrasonography is a valid method to measure changes in skeletal muscle cross-sectional area. European Journal of Applied Physiology, 2010. 108:273–279.

17.   Juha Ahtiainen, Juha J. Hulmi, William J. Kraemer, Maarit Lehti, Arto Pakarinen, Antti A. Mero, Laura Karavirta, Elina Sillanpää, Harri Selänne, Markku Alen, Jyrki Komulainen, Vuokko Kovanen, Kai Nyman, Keijo Häkkinen. Strength, endurance or combined training elicit diverse skeletal muscle myosin heavy chain isoform proportion but unaltered androgen receptor concentration in older men.  International Journal of Sport Medicine 30(12):879-87, 2009.

18.  Antti A. Mero, Tuomo Ojala, Risto Puurtinen, Juha J. Hulmi, Tuomo Karila, Timo Seppälä. Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes. J Int Soc Sports Nutr. 2010 Jan 5;7(1):1.

19.   Antti A. Mero, Heikki Huovinen, Olle Matintupa, Juha J. Hulmi, Risto Puurtinen, Hannele Hohtari, Tuomo A.M.Karila. Moderate energy restriction with high protein diet results in healthier outcome in women. J Int Soc Sports Nutr. 2010 Jan 7:4.

20.  Ahtiainen JP, Lehti M, Hulmi JJ, Kraemer WJ, Alen M, Nyman K, Selänne H, Pakarinen A, Komulainen J, Kovanen V, Mero AA, Häkkinen K. Recovery after heavy resistance exercise and skeletal muscle androgen receptor and IGF-I isoform expression in strength trained men. Journal of Strength and Conditioning Research, 2011, 25: 767-77

21.  Ahtiainen JP, Hulmi JJ, Kraemer WJ, Lehti M, Nyman K, Selänne H, Alen M, Pakarinen A, Komulainen J, Kovanen V, Mero AA, Häkkinen K. Heavy resistance exercise training and skeletal muscle androgen receptor Expression in younger and older men, Steroids, 2011, 76: 183-92.

22. Jan Sundell, Juha Hulmi, Jari Rossi. HERAPROTEIINI JA KREATIINI URHEILURAVINTOLISINÄ [Whey protein and creatine as nutritional supplements]. Lääketieteellinen Aikakauskirja Duodecim. 2011;127(7):700-5

23. Kontro H, Hulmi JJ, Rahkila P, Kainulainen H. Cellular and tissue expression of DAPIT, a phylogenetically conserved peptide. European Journal of Histochemistry, 2012 56:e18.

24. Rita Rinnankoski-Tuikka, Mika Silvennoinen, Sira Torvinen, Juha J. Hulmi, Maarit Lehti, Riikka Kivelä, Hilkka Reunanen, Heikki Kainulainen. Effects of high-fat diet and physical activity on murine muscle mitochondria and PDK4. Nutrition and Metabolism, Nutrition & Metabolism 2012, 9:53.

25. Antti Mero, Juha J. Hulmi, Salmijärvi H, Katajavuori M, Haverinen M, Holviala J, Ridanpää T, Häkkinen K, Kovanen V, Ahtiainen JP, Selänne H. Resistance training induced increase in muscle fiber size in young and older men. European Journal of Applied Physiology, 113:641-50, 2013.

26.  Hoogaars W, Mouisel E, Pasternack A, Hulmi JJ, Relizani K, Schuelke M, Garcia L, Ritvos O, Ferry A, Hoen P, Amthor H. Combined effect of AAV-U7-induced dystrophin exon skipping and soluble activin type IIB receptor in mdx mice. Human Gene Therapy, 12, 1269-79, 2012.

27. Sedliak M, Buzgó G, Cvečka J, Hamar D, Laczo E, Zelko A, Raastad T, Nilsen T, Ahtiainen J, Häkkinen K, Hulmi J. Effects of time of day on resistance exercise-induced anabolic signaling in skeletal muscle. Biological Rhythm Research, Accepted.

28.  Mika Silvennoinen, Rita Rinnakoski-Tuikka, Meri Vuento, Juha J. Hulmi, Sira Torvinen, Maarit Lehtia, Riikka Kiveläa, Heikki Kainulainen et al. High-fat feeding induces angiogenesis and up-regulates the gene expression of angiogenic factors in the skeletal muscle of mice. Angiogenesis, 16, 297-307, 2013.

29. Simon Walker, Juha J. Hulmi, Juha P. Ahtiainen, Mathias Wernbom, Kai Nyman, William J. Kraemer and Keijo Häkkinen. Variable resistance training promotes greater fatigue-resistance but not hypertrophy vs. constant resistance training. European Journal of Applied Physiology, 113: 2233-2244, 2013.

30. Heikki Kainulainen, Juha J. Hulmi, Urho M. Kujala. Potential Role of Branched Chain Amino Acid (BCAA) Catabolism in Regulating Fat Oxidation. Exercise & Sport Sciences Reviews. 41: 194-200, 2013.

31. Satu Pekkala, Petri Wiklund, Juha J Hulmi, Juha P Ahtiainen, Mia Horttanainen, Eija Pöllänen, Kari A Mäkelä, Heikki Kainulainen, Keijo Häkkinen, Kai Nyman, Markku Alen, Karl-Heinz Herzig, and Sulin Cheng. Are Skeletal Muscle FNDC5 Gene Expression and Irisin Release Regulated by Exercise and Related to Health? J Physiol. 591: 5393-5400, 2013.

32. Antti A. Mero, Petri Hirvonen, Janne Saarela, Juha J. Hulmi, Jay R. Hoffman and Jeffrey R. Stout.  Effect of sodium bicarbonate and beta-alanine supplementation on maximal sprint swimming. J Int Soc Sports Nutr. 2013 Nov 11;10(1):52.

33. Riikka Kivelä, Maija Bry, Miia Taavitsainen, Marius Robciuc, Johanna Silvola, Antti Saraste, Juha J. Hulmi, Andrey Anisimov, Lauri Eklund, Sanna Hellberg, Ruslan Hlushchuk, Zhenwu Zhuang, Michael Simons, Valentin Djonov, Juhani Knuuti, Eero Mervaala, Kari Alitalo. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol. Med. 2014 in press.

34. Rita Rinnankoski-Tuikka, Juha J. Hulmi, Sira Torvinen, Mika Silvennoinen, Maarit Lehti, Riikka Kivelä, Hilkka Reunanen, Urho M. Kujala, Heikki Kainulainen. Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change Metabolism. Accepted.

35. Huovinen H, Hulmi JJ et al. Moderate weight reduction improves power performance in male athletes. Journal of Strength and Conditioning Research, 2014

36. Hietavala E, Stout JR, Hulmi JJ, Suominen H, Pitkänen H, Puurtinen R, Selänne H, Kainulainen H, Mero AA. Effect of diet composition on acid-base balance in adolescents, young adults and elderly at rest and during exercise. European Journal of Clinical nutrition In press.

37. Kainulainen H, Papaioannou KG, Silvennoinen M, Autio R, Saarela J, Oliveira BM, Nyqvist M, Pasternack A, Hoen PAC, Kujala UM, Ritvos O, Hulmi JJ. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology in press.

38. Myllärniemi M, Tikkanen J., Hulmi JJ, Pasternack ., Sutinen E, Ronty M, Lepparanta O, Kinnula V, Hongqiang M, Ritvos O, Koli K. Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models. BMC Pulm Med. 2014 Nov 1;14(1):170.

39. Paulsen, G, Hamarsland, H, Cumming, KT, Johansen, RE, Hulmi, JJ, Børsheim E, Wiig H, Garthe I, Raastad T.Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. Journal of Physiology In press.

 

 

Manuscript reviews in peer-review journals:
FASEB Journal 2007-

Journal of Applied Physiology 2008-

Scandinavian Journal of Medicine and Science in Sports 2008-

Journal of Physiology 2009-

Acta Physiologica 2009-

European Journal of Nutrition 2011-

European Journal of Clinical Nutrition 2011-

Nutrition & Metabolism 2011-

BMC Biology 2012-

Review Editor in Frontiers in Clinical and Translational Physiology

 

As an editor and author in a book:

Lääkkeet ja lisäravinteet urheilussa. Eds. (Alaranta A, Hulmi J, Mikkonen J, Rossi J, Mero A. www.nutrimed.fi
As a writer in the following book chapters:

o        Geenidoping. Juha Hulmi and Jari Rossi.

o        Lihaskasvu ja sen säätelymekanismit. Juha Hulmi.

o        Urheilija ja proteiinit. Juha Hulmi and Antti Mero.

o        Beeta-alaniini. Joonas Mikkonen, Juuso Reinikainen and Juha Hulmi.

o        Melatoniini ja urheilu. Antti Mero and Juha Hulmi.

o        Leusiini ja urheilu. Antti Mero and Juha Hulmi.

 

 •Nutrition and Enhanced Sports Performance. α-Hydroxyisocaproic acid (HICA) – effects on body composition, muscle soreness and athletic performance . Tuomo Ojala, Jacob M. Wilson, Juha J. Hulmi, Tuomo Karila, Timo A. Seppälä and Antti A. Mero. Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building, edited by Debasis Bagchi, Shreejayan Nair, and Chandan K. Sen. Accepted for publication.

Personal grants
• The Finnish Cultural Foundation 2005: one year personal grant for PhD research: 16 000 €. Topic: Short- and long-term effect of strength training and protein nutrition on muscle growth mechanisms.
• Ellen and Artturi Nyyssönen Foundation 2007: one year personal grant for PhD research: 14 400 €. Topic: Short- and long-term effect of strength training and protein nutrition on muscle growth mechanisms.

University of Jyväskylä rectoral grant (3 months) for finishing the dissertation during 2009.

 The Finnish Cultural Foundation 2009: one year personal grant for post-doc research: 21 000 €. Topic: The effects of resistance training and protein nutrition on muscle hypertrophy mechanisms.

 The Finnish Academy: Postdoctoral Researcher’s project 2011-2013 230 010 €. Combinatorial effects of physical activity and muscle atrophy and inflammation blocking agents in healthy and diseased skeletal muscle.

 ERASMUS travel grant 2011 1300 € to LUMC, Leiden, Netherlands, 2 weeks

 Mobility grant for research in Melbourne, Baker IDI for 2 months 28.12.-28.2.2013

 ERASMUS teaching grant 2013 1300 € to Comenius University, Bratislava Slovakia 21-29.4.2013

 

 

Teaching experience
Universtity of Jyväskylä, Department of Biology of Physical Activity during 2005-2009:
Demonstration teaching courses:
• Basics of Biology and Human Physiology
• Exercise Physiology I
• Exercise Physiology II: Developed 3/5 of the demonstrations.
• Bases of sport coaching and fitness testing
• Extension course in sport coaching and fitness testing

• Research Design and Methods

• Cell and molecular biology

• Exercise nutrition

• Applied Exercise Physiology

Evaluation of teaching (under-graduate students):
• Teaching practice in exercise physiology
• Teaching practice in sport coaching and fitness testing

+Various courses outside university

Invited international seminar/conference lectures / presentations

Haartman Seminar. University of Helsinki, Faculty of Medicine, Haartman Institute. Topic: Physiological Regulation of Skeletal Muscle Hypertrophy. 11.3.2010.

 Performance Nutrition Symposium: Bridging the Gap Between the Laboratory and the Field. National Strength and Conditioning Association (NSCA). Topic: Protein Timing and Type. 2.10.2010. Columbus, USA.

 Pharmacology and toxicology seminar. University of Oulu, Faculty of Medicine. Topic: Myostatin and Regulation of Skeletal Muscle Hypertrophy. 4.10.2011.

 International symposium. Intensive course. Myostatin and muscle hypertrophy. Jyväskylä 30.11.2011.

 New aspects on exercise for health. Turku PET centre. Skeletal muscle size and its regulation: importance for health.

8th International Conference on Strength training. Cell signaling after resistance exercise: Mechanical vs. metabolic stress, Oslo. 27.10.2012

13th International Symposium: Physical Fitness and Training Adaptation: Scientific Basis and Practical Applications in Sport.Benefits of protein intake during strength training. 23.11. Jyväskylä